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. 2018 Aug 28;9(9):847. doi: 10.1038/s41419-018-0838-9

Fig. 2. Effects of HIPK2 on sepsis-induced lethality and production of liver injury-related factors in CLP-induced mice.

Fig. 2

a HIPK2 was overexpressed following the injection of Ad-HIPK2 and HIPK2 was knocked down following the injection of Ad-shHIPK2, and hepatic HIPK2 expression was analysed by Q-PCR; the data are presented as means ± SEM (n = 3), #p < 0.05 compared with the Ad-vector group. b The expression of HIPK2 in several different tissues was analysed by Q-PCR; the data are presented as means ± SEM (n = 3), #p < 0.05 compared with the Ad-vector group. c Effect of HIPK2 on the survival of mice with CLP-induced sepsis; the data are presented as means ± SEM (n = 30 mice per group), #p < 0.05 compared with the sham plus Ad-vector group, + p < 0.05 compared with the CLP plus Ad-vector group. In this section, the CLP was performed on the fifth day after the adenovirus injection, and the liver and serum were obtained 16 h after CLP-induced sepsis. d, e, f Effect of HIPK2 on serum AST, ALT, and ALP concentrations, as determined by ELISAs; the data are presented as means ± SEM (n = 30 mice per group), #p < 0.05 compared with the sham plus Ad-vector group, + p < 0.05 compared with the CLP plus Ad-vector group. g, h, i Effect of HIPK2 on liver AST, ALT, and ALP levels, as analysed by ELISAs; the data are presented as means ± SEM (n = 30 mice per group), #p < 0.05 compared with the sham plus Ad-vector group, + p < 0.05 compared with the CLP plus Ad-vector group