Fig. 3. Effects of HIPK2 on the levels of inflammatory cytokines and oxidative stress-related markers in CLP-induced mice.

The CLP surgery was performed on the fifth day after the adenovirus injection and the liver and serum were obtained 16 h after CLP-induced sepsis. a, b, c Serum TNF-α, IL-1β and IL-6 concentrations were determined using ELISAs; data are presented as means ± SEM (n = 30 mice per group), #p < 0.05 compared with the sham plus Ad-vector group, + p < 0.05 compared with the CLP plus Ad-vector group. d–i Liver CAT (d), GSH (e), SOD (f), H₂O₂ (g), NO (h), and O^.−₂ (i) concentrations were measured using ELISAs; data are presented as means ± SEM (n = 30 mice per group), #p < 0.05 compared with the sham plus Ad-vector group, + p < 0.05 compared with the CLP plus Ad-vector group