Fig. 5. HIPK2 overexpression restores autophagosome formation in CLP-induced mice.
a Effect of HIPK2 overexpression on Beclin-1 and Atg12-5 levels, as analysed by western blotting; CLP (n = 30) was performed on the fourth day after the adenovirus injection. Data are presented as means ± SEM and are representative of three separate experiments; #p < 0.05 compared with the sham plus Ad-vector group (control), + p < 0.05 compared with the CLP plus Ad-vector group. b Effect of HIPK2 overexpression on Atg3 and Atg7 levels, as analysed by western blotting. Data are presented as means ± SEM and are representative of three separate experiments, #p < 0.05 compared with the sham plus Ad-vector group, + p < 0.05 compared with the CLP plus Ad-vector group