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. 2018 Aug 28;9(9):855. doi: 10.1038/s41419-018-0900-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Three differentially expressed genes (CD44, ABCB1, and MYC) and AF1q were detected by qRT-PCR to verify microarray analyses. b AF1q and CD44 levels in bone marrow samples from newly diagnosed CP CML patients (n = 72) were determined by qRT-PCR and normalized to β-actin. A positive correlation was observed between AF1q and CD44 expression in CP CML patients. c Heat map for AF1q and CD44 mRNA expression in CP CML patients (n = 72). Columns represented CML patients and rows represented AF1q and CD44 expression. Colors from dark to light indicated high to low relative expression of AF1q and CD44. d, e CD44 levels were evaluated in CD34⁺ and CD34⁻ cells isolated from newly diagnosed CP CML patients (n = 13) by qRT-PCR and normalized to β-actin. Results were analyzed by unpaired (d) and paired (e) Student t tests. f A positive correlation was observed between AF1q and CD44 expression in CD34⁺ CML cells (n = 13)