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. 2018 Aug 22;9:1900. doi: 10.3389/fmicb.2018.01900

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Copyright © 2018 Olivares, Schüppel, Hassan, Beaumont, Neyrinck, Bindels, Benítez-Páez, Sanz, Haller, Holzer and Delzenne.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Theoretical scenarios in which the Dipeptidyl peptidase-4 and PepX activities produced by the gut microbiota might impact host's health through the proteolysis of different substrates with a biological activity. Glucagon-like peptide-1 (GLP)-1, gastric inhibitory polypeptide (GIP), and peptide YY (PYY) are represented in color (purple, green and blue, respectively) when not cleaved by DPP-4 and PepX activities. The corresponding symbols are represented in black after the cleavage by DPP-4 and PepX activities.