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. 2018 Aug 22;9:1916. doi: 10.3389/fimmu.2018.01916

Figure 4.

Figure 4

Overexpressing miR-223 reduces LPS-induced IL-1β secretion. BEND cells were transfected with miR-223 mimics (agomiR-223) at different concentrations (0, 10, 20, 50 nmol) for 24 h, and qPCR was used to detect miR-223 expression. (A) BEND cells were transfected with miR-223 mimics, followed by 2 h of exposure to LPS (0.5 μg/ml); the proinflammatory cytokines IL-1β, TNF-α, and IL-6 were detected by qPCR (B) and ELISA (C). NC stands for cell transfected with the corresponding control oligonucleotide. Data represent three independent experiments and are presented as the mean ± S.E.M (error bars). Two tailed, student t-test, *P < 0.05; **P < 0.01.