Figure 4.

Apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like (APOBEC) family gene expression‐associated clinical outcomes in TCGA pan‐cancers. APOBEC family gene expression in database (http://www.proteinatlas.org/pathology)67 with 17 major cancer types with respect to clinical outcome was analyzed for Kaplan‐Meier survival plot. No APOBEC3A expression is associated with clinical outcome; however, higher expression of APOBEC3B, C, D, G, H genes show poor survival time in renal cancer. In contrast, better survival time is seen in cervical cancer. Breast cancer benefits from higher expression of APOBEC3D and APOBEC3G; urothelial cancer benefits from higher expression of APOBEC3D, F, H; and endometrial cancer show better survival time with higher expression of APOBEC3G. Purple lines represent higher expression of APOBEC3; blue lines represent lower expression of APOBEC3