Table 5.

Population pharmacokinetic models developed for critically ill patients

N	Pharmacokinetic model	Pharmacokinetic parameters	Covariates	Reference
206	One compartment	Cl = 4.6L/h Vd = 1.5L/kg	Cl = 4.6 × Clcr/100 ABW (covariate of Vd)	31
46	One compartment	Cl = 0.86 mL/min/kg Vd = 1.69 L/kg	Cl = 0.872 − 0.015 × age (years) − 0.007 × ApII + 0.234 × Ab + 0.346 ClcrL (mL/min/kg) ABW (covariate of Vd)	32

Ab, serum albumin (g/dL); ABW, actual body weight; ApII, APACHE II score; Cl, vancomycin clearance; Clcr, creatinine clearance; ClcrL, creatinine clearance by the Levey formula; N, Sample size; Vd, volume of distribution.