Table 6.

Guidelines review of pediatric patients' considerations

Question	Answer (LoE/GoR)	Guideline
Pediatric patients	1. First trough concentration can be obtained before the fourth dose (on day 2 if administered every 6 h). (C/1) 2. Vancomycin 15 mg/kg every 6 h is recommended for infants and children, and doses should be adjusted according to the result of TDM. Although few data are available to guide the dosing regimen in adolescent patients of ≥12 years old, doses of 15 mg/kg may be given every 8 h. (C/1) 3. To date, there are limited data to support the efficacy and safety of targeting trough concentrations of 15–20 mg/L in children, and additional study is required. (Unresolved issue)	2013, JPN3

GoR, grade of recommendation; JPN, Japanese; LoE, level of evidence; TDM, therapeutic drug monitoring.