Table 8.

Guidelines review of impaired renal function patients' considerations

Question	Answer (LoE/GoR)	Guideline
Patients with impaired renal function	1. Standard or reduced single doses are given every 24 h or at even longer intervals according to renal function. (C/1)	2013, JPN3
	2. To facilitate rapid attainment of target trough concentration, experts recommend an initial loading dose regardless of renal function. (C/1)
	3. As no nomogram predicts vancomycin concentrations precisely especially in patients with impaired renal function, dose should be adjusted individually based on measured vancomycin concentrations. (B/1)

GoR, grade of recommendation; JPN‐Japanese; LoE, Level of evidence.