Table 13.

Population pharmacokinetic models developed for neurosurgery patients

N	Pharmacokinetic model	Pharmacokinetic parameters	Covariates	Reference
25	Three‐compartment	V1 = 15.16 L; V2 = 46.10 L; VCSF = 0.14 L; Q = 3.97 L/h; QCSF = 0.006 L/h; Cl = 7.98 L/h; ClCSF = 0.038 L/h	CSF albumin level	94

Cl CSF, cerebrospinal clearance; Cl, clearance; N, sample size; Q, intercompartmental distribution; QCSF, cerebrospinal distribution; V1, volume of central compartment; V2, volume of peripheric compartment; VCSF, volume of cerebrospinal fluid.