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. 2018 Jun 27;109(8):2342–2348. doi: 10.1111/cas.13655

Figure 1.

Figure 1

Epigenetic regulation by polycomb group (PcG) complexes. Canonical and non‐canonical PRC1 ubiquitinate H2AK119 with or independently of PRC2, respectively, resulting in transcriptional repression. A, EZH1/2 trimethylates H3K27, and the recruitment of canonical PRC1 to target sites is mediated by the recognition of H3K27me3 by CBX, followed by PRC1 ubiquitination of H2AK119. B, Non‐canonical PRC1 ubiquitinates H2AK119 independently of PRC2. H2AK119ub1 then recruits PRC2 to target genes and induces the trimethylation of H3K27. EZH1/2, enhancer of zeste homolog 1 and 2; PRC, polycomb repressive complexes