Figure 3.

Modified chlorambucil (Chb‐M') as a safe lead compound of novel anticancer drug therapy. Chb‐M' targets the consensus Runt (Runt domain)‐related transcription factor (RUNX)‐binding sequences on the genome DNA and achieves “cluster regulation of RUNX,” which offers efficient antitumor activity through potentiating the pro‐apoptotic p53‐mediated cell death pathway. CBFβ, core‐binding factor β. Modified from Morita K, Suzuki K, Maeda S, et al. Genetic regulation of the RUNX transcription factor family has antitumor effects. J Clin Invest. 2017;127:2815–282819, by permission of American Society for Clinical Investigation.

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