TABLE 5.
Performance of FluoroType MTBDR for detection of MDR-TB from smear-positive and smear-negative sputum specimens when using Sanger sequencing and GenoType MTBDRplus as reference methodsa
| Specimen | Sensitivity |
Specificity |
Positive LR (95% CI) | Negative LR (95% CI) | No. of indeterminate results | ||
|---|---|---|---|---|---|---|---|
| % (95% CI) | No. of specimens positive/total no. tested | % (95% CI) | No. of specimens positive/total no. tested | ||||
| All (n = 315) | 99.3 (95.8–100) | 148/149 | 100 (97.2–100) | 166/166 | Infinity (NaN–infinity) | Infinity (NaN–infinity) | 7 |
| Sputum smear positive (n = 228) | 99.1 (94.3–100) | 108/109 | 100 (96.1–100) | 119/119 | Infinity (NaN–infinity) | 0.09 (0.001–0.06) | 4 |
| Sputum smear negative (n = 87) | 100 (89.1–100) | 40/40 | 100 (90.6–100) | 47/47 | Infinity (NaN–infinity) | Infinity (NaN–infinity) | 3 |
a
Definitions of abbreviations: ind, indeterminate; CI, confidence interval; LR, likelihood ratio; NaN, the calculation could not be performed because the values entered included one or more instances of zero.