TABLE 6.
Accuracy of FluoroType MTDR to detect specific mutations in rpoB identified by Genotype MTBDRplus and sequencinga
| rpoB genotype | No. of isolates for which the genotype was: |
% of isolatesb | ||||||
|---|---|---|---|---|---|---|---|---|
| Identified by MTBDRplus or sequencing | Correctly identified by FluoroType MTBDR | Incorrectly identified by FluoroType MTBDR |
||||||
| Indeterminate | False resistance | Incorrect mutation | Undifferentiated mutation | Only WT was recorded | ||||
| WT | 138 | 135 | 2 | 1 | 97.8 | |||
| S531L | 135 | 133 | 2 | 98.5 | ||||
| Q513P | 1 | 0 | 1 | 0 | ||||
| Het/mixed | 11 | 9 | 1 | 1 | 81.1 | |||
| Totalc | 322 | 314 | 97.5 | |||||
a
Definitions of abbreviations: WT, wild type; Het/mixed, heteroresistance and/or mixed infection.
b
Genotypes identified with 100% accuracy by FluoroType MTBDR: H526D (9/9), H526Y (7/7), D516V (4/4), D516Y (3/3), H526N (3/3), L533P (2/2), insertion between codons 514 and 515 (1/1), L511P (2/2), H526L (2/2), H526R (1/1), S531F (1/1), Q513K (1/1), and H526P (1/1).
c
The total includes the results for genotypes identified with 100% accuracy.