Figure 3.

Connexin 43 (Cx43) expression inversely correlates with Akt and ERK phosphorylation in glioblastoma (GBM) patients with epidermal growth factor receptor (EGFR) overexpression. A, Double immunofluorescence staining of EGFR and Cx43 in GBM patients. Scale bar = 50 μm. B–E, Immunohistochemical analysis of Cx43, phosphorylated (p‐)Akt, and p‐ERK in EGFR+ GBM patients. Scale bar = 50 μm. Nuclear accumulation of p‐Akt and p‐ERK is indicated by red arrowheads. Correlations between the expression of Cx43 and p‐Akt/p‐ERK were calculated with Pearson's correlation analyses