Table 1.
Water Maze Test
| CA/CPR 10min |
CA/CPR 10min |
|||||
|---|---|---|---|---|---|---|
| Saline (n = 31) | Pravastatin (n = 31) | Simvastatin (n = 30) | Lipid Emulsion (n = 32) | |||
| Before CA/CPR | ||||||
| First position of escape platform | ||||||
| First attempt prior to CA/CPR | Day 5 | Time(s) | 14 (7–30) | 17 (8–34) | ||
| Last attempt prior to CA/CPR | Day 1 | Time(s) | 6 (2–17)∗ | 9 (4–15)∗ | ||
| After CA/CPR | ||||||
| First position of escape platform (remembrance of position) | ||||||
| First attempt after CA/CPR | Day X | Time(s) | 11 (4–27) | 10 (5–18) | 14 (9–27) | 22 (14–45) |
| Last attempt after CA/CPR | Day X+2 | Time(s) | 7 (4–13) | 5 (3–14) | 9 (4–14) | 8 (4–23) |
| Alternative position of escape platform (new spatial learning) | ||||||
| First attempt new position | Day 10 | Time(s) | 18 (10–32) | 13 (7–25) | 17 (10–35) | 18 (15–35) |
| End of training phase | Day 15 | Time(s) | 8 (4–12)† | 5 (3–10)∗ | 13 (5–17) | 8 (6–13)∗ |
| Participation in the water maze test after CA/CPR | ||||||
| Participants after CA/CPR | n (%) | 8 (25.8) | 17 (54.8)‡ | 9 (30) | 9 (28.1) | |
| Earliest day of participation after CA/CPR (day X) | 5 (3–8) | 3 (2–5)‡ | 5 (4–7) | 6 (5–8) | ||
Values are median (25th–75th percentiles).
CA = cardiac arrest; CPR = cardiopulmonary resuscitation.
∗
p < 0.05: day 5 versus day 1.
†
p < 0.05: day 15 versus day 10.
‡
p < 0.05 pravastatin versus saline. Data analysis by Wilcoxon matched-pairs signed-rank test.