Table 2.
Multivariable analysis of associations between demographic and clinical characteristics and mean joint bleeds per 6-month period in 4771 males with mild or moderate hemophilia
| Characteristic | Estimate | Standard error | χ2 | P |
|---|---|---|---|---|
| Age group, y | ||||
| 2-9 | Ref | |||
| 10-24 | 1.02 | 0.08 | 146.0 | <.001 |
| 25-44 | 0.82 | 0.11 | 52.5 | <.001 |
| 45+ | 0.27 | 0.12 | 2.2 | .03 |
| Race/ethnicity | ||||
| White | Ref | |||
| African American | 0.33 | 0.10 | 11.3 | <.001 |
| Hispanic | −0.28 | 0.09 | 9.0 | <.01 |
| Other | 0.25 | 0.12 | 4.1 | .04 |
| Insurance | ||||
| Commercial | Ref | |||
| Medicaid/Medicare | 0.41 | 0.07 | 38.9 | <.001 |
| Other | −0.004 | 0.12 | 0.0 | .9 |
| Uninsured | 0.18 | 0.11 | 2.7 | .1 |
| BMI | ||||
| Normal | Ref | |||
| Underweight | −0.26 | 0.37 | 0.5 | .5 |
| Overweight | −0.05 | 0.07 | 0.6 | .5 |
| Obese | −0.08 | 0.07 | 1.2 | .3 |
| Hemophilia type | ||||
| FVIII | Ref | |||
| FIX | −0.59 | 0.06 | 87.4 | <.001 |
| HIV infection | ||||
| Negative | Ref | |||
| Positive | 0.33 | 0.11 | 8.5 | <.01 |
| Hepatitis C infection | ||||
| Negative | Ref | |||
| Positive | 0.94 | 0.08 | 133.6 | <.001 |
| Hepatitis B infection* | ||||
| Negative | Ref | |||
| Positive | 0.28 | 0.21 | 1.8 | .2 |
| Baseline FA level | −0.09 | 0.004 | 431.8 | <.001 |
The regression model included at a minimum the covariates of age group, race/ethnicity, insurance type, BMI category, hemophilia type, hepatitis B and C, HIV status, and baseline FA level.
Ref, reference.
*
Hepatitis B infection is based on a positive hepatitis B surface antigen test result.