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. 2018 Jul 8;141(9):2700–2710. doi: 10.1093/brain/awy183

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© The Author(s) (2018). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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PK-resistant PrP in scrapie-exposed PrP transgenic Drosophila. Elav × VRQ(GPI) PrP transgenic (VRQ) and Elav × 51D (51D) Drosophila were exposed at the larval stage to PG127 scrapie-infected or prion-free control sheep brain material. At 30 days post-hatching, head homogenate was prepared from harvested flies, treated with PK and analysed by western blot to detect PK-resistant PrP. (A and B) Drosophila exposed to control brain homogenate. (C and D) Drosophila exposed to PG127 scrapie-infected sheep brain homogenate. (A and C) Elav × 51D Drosophila. (B and D) Elav × VRQ(GPI) PrP transgenic Drosophila. A titration of original PG127 scrapie-infected sheep brain homogenate is included on each blot for comparative purposes. Molecular mass markers in kDa shown in the centre.