Figure 3.

Network structure of negatively enriched gene sets in amyloid-vulnerable brain regions. Negatively enriched gene sets (blue circles) are plotted in a graph structure, where the overlap in gene members between different gene sets is indicated by the width of cyan lines. Gene sets are numbered according to their order in Table 2 and circle diameters reflect the size of each gene set. The matrix plot below shows the cluster structure of the leading-edge genes of the enriched gene sets (hierarchical clustering with average linkage). Each column corresponds to a leading-edge gene as detailed in Supplementary Table 1. Rows 1–14 contain the leading-edge genes of gene sets in cluster A1, rows 15–17 those of gene sets in cluster A2.