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. 2018 Aug 1;141(9):2685–2699. doi: 10.1093/brain/awy193

Figure 2.

Figure 2

Evidence of tau pathology in mouse TBI. AT8 immunostaining and quantification of the AT8-positive area in the ipsilateral and contralateral cortex of sham and TBI mice at 3 and 12 months post-injury. (A and B) AT8 immunoreactivity is detected in the ipsilateral (ipsi) pericontusional cortical area in two of four mice at 3 months post-TBI, and in all mice at 12 months. (C and D) In the contralateral cortex AT8 immunoreactivity is detected only after 12 months post-TBI. Data are mean ± SEM; n = 4–5; *P < 0.05; **P < 0.01 by one-way ANOVA, Tukey post hoc test. Scale bar = 100 µm (B and D).