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. 2018 Aug 1;141(9):2685–2699. doi: 10.1093/brain/awy193

Figure 5.

Figure 5

Memory deficits are already detected at 4 months post-inoculation. (A) Scheme of the groups of mice used in the inoculation studies. C57BL/6J male mice were either left untreated (open bar) or inoculated bilaterally into the hippocampus and overlaying cerebral cortex with 10% brain homogenates from sham (grey) or TBI (contused hemisphere, indigo) mice 12 months post-injury. (B and C) Recognition memory was investigated by novel object recognition (NOR) test at 4 (B) and 8 (C) months after inoculation. Histograms indicate the discrimination index (the higher the discrimination index the better the performance). (D and E) Locomotor activity was similar in sham and TBI inoculated mice at 4 (D) and 8 (E) months after inoculation. Data are mean ± SEM, n = 11–14. ***P < 0.001, **P < 0.01 versus naïve; ##P < 0.01 versus sham; by one-way ANOVA, Tukey post hoc test.