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. 2018 Aug 22;9:884. doi: 10.3389/fphar.2018.00884

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Copyright © 2018 Du, Wang, Liu, Wang, Su, Zhang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The workflow of our work. The Discovery phase (Cohort 1, 36 subjects), Validation phase (Cohort 2, 75 subjects) and Statistical (Cohort 2, 75 subjects) analyses phase were incorporated into our study. MM, multiple myeloma; AG, active MM patients also named as symptomatic myeloma; RG, MM patients responding to chemotherapy; HC, healthy controls.