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. 2018 Aug 22;9:884. doi: 10.3389/fphar.2018.00884

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Copyright © 2018 Du, Wang, Liu, Wang, Su, Zhang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PCA and OPLS-DA of the metabolic profiles of serum samples in HC, RG, and AG groups of Discovery phase analyzed by C₁₈ and HILIC column chromatography. (A), PCA analysis in C₁₈ mode; (B), OPLS-DA analysis in C₁₈ mode; (C), PCA analysis in HILIC mode; (D), OPLS-DA analysis in HILIC mode. Red nodes, blue nodes and green nodes respectively represented the samples of the subjects in AG, RG, and HC groups. PCA: principal components analysis; OPLS-DA: orthogonal partial least-squares-discriminant analysis; HILIC: hydrophilic interaction liquid chromatography. The HC, RG, and AG groups in Discovery phase included 14, 10, 12 subjects, respectively.