Table 1.
Baseline clinical data of 22 cases of MM patients in Cohort 1.
| Characteristics | Overall | Groups | P-value | |
|---|---|---|---|---|
| Active group (AG) | Responding group(RG) | |||
| Numbers | 22 | 12(NDMM 4/RMM 8) | 10 | |
| Age (years) | 61.1 | 63.5 | 57.9 | 0.223 |
| Gender: M/F | 14/8 | 8/4 | 6/4 | 0.746 |
| TYPE OF MM | ||||
| Ig G(%))/Ig A/Ig D/κ/λ/NS | 12(54.5%) /3/2/2/3/0 | 6(50.0%)/1/2/1/2/0 | 6(60.0%)/2/0/1/1/0 | 0.644 |
| Stage of R-ISS: I/II/III | 3(14%)/11(50%)/8(36%) | 1(8%)/5(42%)/6(50%) | 2(20%)/6(60%)/2(20%) | 0.323 |
| MM with EMP | 3(13.6%) | 2(16.7%) | 1(10.0%) | 0.650 |
| HIGH-RISK CYTOGENETICS | ||||
| FISH del(17p)/1q21/IGH | 3/4/9(n = 18) | 2/4/4(n = 10) | 1/0/5(n = 8) | 0.159 |
| Plasma cell (%) | 12.5 ± 3.7 | 21.6 ± 45.6 | 31.5 ± 0.4 | 0.001 |
| Calcium > 2.75 mmol/L | 1 | 1 | 0 | 0.350 |
| Creatinine > 177 mmol/L | 3(13.6%) | 3(25.0%) | 0(0.0%) | 0.089 |
| Hemoglobin < 10 g//L | 8(36.4%) | 7(58.3%) | 1(10.0%) | 0.019 |
| Bone lesions | 17(77.3%) | 10(83.3%) | 7(70.0%) | 0.457 |
| LDH > 240 U/L | 12(54.5%) | 8(66.7%) | 4(40.0%) | 0.211 |
| β2−MG > 5.5 mg/dl | 6(27.3%) | 6(50.0%) | 0(0.0%) | 0.009 |
| Albumin < 35 g/L | 5(22.7%) | 3(25.0%) | 2(20.0%) | 0.781 |
| Calcium (mmol/L) | 3.2 ± 0.9 | 4.0 ± 0.5 | 2.2 ± 0.05 | 0.300 |
| Creatinine (umol/L) | 149.5 ± 38.0 | 214.8 ± 63.9 | 62.7 ± 12.7 | 0.004 |
| Hemoglobin (g/L) | 107.4 ± 6.3 | 93.2 ± 8.3 | 124.5 ± 46.4 | 0.043 |
| Globulin (g/L) | 31.7 ± 3.3 | 38.1 ± 5.3 | 23.7 ± 1.3 | 0.001 |
| Amount of IgG (g/L) | 27.8 ± 5.6 | 38.5 ± 7.0 | 15.9 ± 3.8 | 0.018 |
| TC (mmol/L) | 4.6 ± 0.2 | 4.6 ± 0.3 | 4.7 ± 0.3 | 0.922 |
| TG (mmol/L) | 2.3 ± 0.4 | 2.2 ± 0.5 | 2.5 ± 0.6 | 0.631 |
| HDL-C (mmol/L) | 1.0 ± 0.07 | 0.9 ± 0.05 | 1.1 ± 0.06 | 0.165 |
| LDL-C (mmol/L) | 2.6 ± 0.1 | 2.3 ± 0.2 | 2.9 ± 0.2 | 0.055 |
M, male; F, female; MM, multiple myeloma; NDMM, newly-diagnosed patients with MM; RMM, relapsed patients with MM; R-ISS, Revised International Staging System; FISH, fluorescence in situ hybridization; LDH, Lactate dehydrogenase; β2-MG, β2-microglobulin; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; Ig G, immunoglobulin G; Ig A, immunoglobulin A; Ig D, immunoglobulin D; NS, non-secretory.