Table 1.

Study characteristics of 24 studies included in pooled analysis.

Investigator	Location	Type of study	Study of design	Study population	Mean follow-up	Endpoint	Quality score
Kanda et al., 2002	Japan	SC	PS	Patients with symptomatic Brugada syndrome	38 months	Apparent syncope, SCD/VF documented in the storage memory of the ICD	16
Masaki et al., 2002	Japan	SC	PS	Patients identified with an ECG pattern consisting of right bundle branch block with ST elevation in leads V 1–V 3	36 ± 24 months	Sudden death	16
Priori et al., 2002	Italy	MC	PS	Patients with presence of ST-segment elevation ≥2 mm in leads V 1–V 3 at baseline	34 ± 44 months	Documented cardiac arrest	16
Mok et al., 2004	Hong Kong	MC	PS	Patients with type 1 Brugada ECGs	25.8 ± 10.9 months	Syncope/syncopal ventricular arrhythmia/sudden death/appropriate ICD shock	20
Furushima et al., 2005	Japan	SC	PS	Patients with Brugada syndrome	33 ± 16 months	VT/VF/completion of the programmed stimulation protocol	16
Kharazi et al., 2007	IRAN	SC	PS	Patients with Brugada syndrome underwent ICD implantation	27.83 ± 11.25 months	VF/VT/completion of EPS protocol	16
Ohkubo et al., 2007	Japan	SC	PS	Patients with Brugada syndrome	47.1 ± 33.7 months	Sudden cardiac death	16
Sarkozy et al., 2007	Belgium/ Holland	SC	PS	Patients underwent an ICD implantation with the diagnosis of BS	47.5 months	Appropriate shocks	16
Benito et al., 2008	Spain	MC	PS	Patients with Brugada syndrome	58 ± 48 months	SCD/documented VF	16
Morita et al., 2008	Japan	MC	PS	Patients with Brugada-type ECG	43 ± 25 months	SCD/VF/non-cardiac death	20
Sacher et al., 2008	Europe	MC	PS	Patients with a type1 Brugada pattern on at least one baseline ECG/ after provocation with a class I antiarrhythmic drug	4 ± 3 years	Appropriate shocks	16
Giustetto et al., 2009	Italy	MC	PS	Patients with Brugada-type ECG	30 ± 21 months	Arrhythmic events (sudden death/VF)	16
Schukro et al., 2010	Austria	MC	PS	Patients with characteristic ECG either at rest or after provocation with Ajmaline	60.7± 44.2 months	VF	16
Sarkozy et al., 2011	Belgium/ Spain	SC	PS	Patients with diagnostic coved type I ECG	59 months	Sudden death	16
Priori et al., 2012	Italy	MC	PS	Patients with type 1 ECGs, without history of cardiac arrest	36 ± 8 months	The occurrence of VF or appropriate ICD interventions	16
Sacher et al., 2013	France	SC	PS	Patients with type 1 Brugada ECGs with implantable cardioverter-defibrillator	77 ± 42 months	Aborted sudden cardiac arrest/syncope	15
Son et al., 2013	Korea	MC	PS	Patients with BrS and underwent ICD therapy	59 ± 46 months	Appropriate shocks	16
Tokioka et al., 2014	Japan	SC	RS	Patients with a Brugada-type ECG	45.1 ± 44.3 months	VF/SCD	16
Conte et al., 2015	Belgium	SC	RS	Presenting with spontaneous or drug-induced Brugada type 1 ECG and underwent ICD institution	83.8 ± 57.3 months	Appropriate shocks	16
Sieira et al., 2015	Belgium	SC	PS	Patients with spontaneous or drug-induced Brugada type I ECG	73.2 ± 58.9 months	SCD/ICD shock	16
Andorin et al., 2016	Europe	MC	PS	Patients with Brugada ECG under 19 years of age	54 months	Sudden death/documented VT or VF/appropriate ICD shock	16
Calò et al., 2016	Italy	MC	PS	Patients with spontaneous type 1 BrS ECG phenotype	48 ± 38.6 months	VF/SCD	16
de Asmundis et al., 2017	Belgium	SC	PS	Patients with type 1 Brugada ECG pattern	10.1 ± 4.6 years	SCD/ICD shock	16
Yamagata et al., 2017	Japan	MC	PS	Patients with type 1 Brugada ECG pattern	72 months	Documented atrial fibrillation/appropriate ICD interventions	16

BrS, Brugada syndrome; ECG, electrocardiogram; ICD, implantable cardioverter defibrillator; MC, multi-center study; PS, prospective study; RS, retrospective study; SC, single center study; SCD, sudden cardiac death; VF, ventricular fibrillation; VT, ventricular tachycardia; MINOR, methodological index for non-randomized studies.