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Proposed algorithm for molecular diagnosis in VEO-IBD. VEO-IBD: very early-onset inflammatory bowel disease; CBC: cell blood count; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; Ig: immunoglobulin; GI: gastro-intestinal; AI: autoimmune; Ab: antibodies; Treg: regulatory T cells; small bowel inflam: small bowel inflammation; TNGS: targeted next-generation sequencing; WES: whole exome sequencing; WGS: whole genome sequencing.
