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. 2018 Aug 22;9:957. doi: 10.3389/fphar.2018.00957

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Copyright © 2018 Liu, Chen, Liu, Zhang, Huang, Xiong and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibitory effects of the known effective fractions and the known effective components in Shenmai Formula on OATP1B3-mediated uptake of OPD (8 μM). The series of concentrations of SMI, GTS, PDG, PDG+PTG, Rb1+Rd, and Rb1+Rd+Re+Rg1 were presented in terms of that of Rb1, PTG, and Re+Rg1 in terms of Re. The uptake of OPD was calculated by subtracting the uptake in control cells from that in transporter-expressing cells, and results were shown as the percentage of uptake of the control (mean ± SD, n = 3). “^∗” represents p < 0.05, “^∗∗” represents p < 0.01 compared to the control group.