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. 2018 Aug 22;9:957. doi: 10.3389/fphar.2018.00957

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Copyright © 2018 Liu, Chen, Liu, Zhang, Huang, Xiong and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibitory effects of the preliminarily separated fractions and the secondary separated fractions of SMI obtained by HPLC on the OATP1B1/1B3 mediated uptake of OPD (8 μM). The series of concentrations of SMI-3, SMI-1+2+3+4, and SMI-3-1 were presented in terms of that of Rb1, SMI-3-3 in terms of Re. SMI-2 and SMI-1+2+4 in terms of dilution factors. The uptake of OPD was calculated by subtracting the uptake in control cells from that in transporter-expressing cells, and the results were shown as the percentage of the control (mean ± SD, n = 3). “^∗” represents p < 0.05, “^∗∗” represents p < 0.01 compared to the control group.