Table 1.
Half-maximal inhibitory concentrations (IC50) (μM) of the known effective fractions, the known effective components and the HPLC separation fractions in SMI on the uptake of OPD in rat primary hepatocytes, OATP1B1- and OATP1B3-HEK293T cells.
| Rat primary hepatocytes | OATP1B1-HEK293T cells | OATP1B3-HEK293T cells | |
|---|---|---|---|
| SMI | 0.66 | 1.28 | 0.52 |
| GTS | 0.67 | 1.19 | 0.35 |
| PDG | 0.94 | 1.13 | 0.46 |
| PTG | INVALD | INVALD | 2.44 |
| PDG+PTG | 0.83 | 1.39 | 0.43 |
| Rb1 | 0.89 | 1.64 | 0.57 |
| Rd | 0.44 | 1.98 | 0.32 |
| Rb1+Rd | 0.87 | 1.52 | 0.5 |
| Rg1 | INVALD | INVALD | 4.18 |
| Re | INVALD | INVALD | INVALD |
| Rg1+Re | INVALD | INVALD | 3.79 |
| Rb1+Rd+Rg1+Re | 0.71 | 1.04 | 0.45 |
| SMI-1 | N.D | INVALD | INVALD |
| SMI-2 | N.D | INVALD | 3.39 |
| SMI-3 | N.D | 1.48 | 0.5 |
| SMI-4 | N.D | INVALD | INVALD |
| SMI-1+2+4 | N.D | INVALD | 2.65 |
| SMI-1+2+3+4 | N.D | 1.33 | 0.48 |
| SMI-3-1 | N.D | 1.94 | 0.55 |
| SMI-3-2 | N.D | INVALD | INVALD |
| SMI-3-3 | N.D | 1.66 | 0.31 |