Table 2.
Main pharmacokinetic parameters of OPD in rats after intravenous administration of OPD (group A) and mixture of OPD+ginsenoside Rb1+ ginsenoside Rd (group B) at the same dose of 77.0 μg/kg OPD (n = 6).
| Parameters | Group A | Group B |
|---|---|---|
| MRT0−t(min) | 19.08 ± 1.53 | 27.89 ± 5.90∗∗ |
| t1/2(min) | 16.79 ± 1.23 | 34.27 ± 10.14∗ |
| CL(L/min/kg) | 0.051 ± 0.016 | 0.020 ± 0.06∗∗ |
| Cmax(ng/ml) | 89.10 ± 30.24 | 157.14 ± 40.35∗ |
| AUC0−t(ng/ml∗min) | 1579.17 ± 551.06 | 4102.49 ± 1325.19∗∗ |
| AUC0−∞(ng/ml∗min) | 1634.86 ± 523.30 | 4245.05 ± 1369.97∗∗ |
| Mean Weight (g) | 213.0 ± 14.9 | 214.7 ± 14.2 |
| Normalized Cmax(ng/ml) | 5.38 ± 1.58 | 9.47 ± 2.22∗ |
| Normalized AUC0−t(ng/ml∗min) | 95.07 ± 28.07 | 247.21 ± 75.13∗∗ |
| Normalized AUC0−∞(ng/ml∗min) | 98.57 ± 26.23 | 255.80 ± 77.74∗∗ |
For the dose normalization, Cmax, AUC0−t and AUC0−∞ were divided by the given dosing of OPD (μg), respectively. ∗p < 0.05, ∗∗p < 0.01 compared to group A, an unpaired Student’s t-test was used for the comparison.