Table 1.
Expanded criteria used for liver transplantation
| Criteria | Type of donor | Detailed criteria |
| UCSF[9,27] | Cadaveric | Solitary tumor ≤ 6.5 cm or ≤ 3 tumors with the largest ≤ 4.5 cm |
| Up-to-seven[10] | Cadaveric/LDLT | Seven: sum of tumor number and size of the largest tumor without microvascular invasion |
| Clinica Universidad de Navara (CUN)[12] | Cadaveric | 1 tumor ≤ 6 cm or ≤ 3 tumors with the largest ≤ 5 cm |
| Toso[29] | Cadaveric | Total tumor volume ≤ 115 cm3 and AFP ≤ 400 ng/mL |
| Hangzhou University[13] | Cadaveric | One of the following: Total tumor diameter ≤ 8 cm Total tumor diameter > 8 cm with histological grade I or II and AFP ≤ 400 ng/mL |
| Onaca (ITR)[32] | Cadaveric | Solitary tumor, ≤ 6 cm 2-4 tumors, ≤ 5 cm |
| Tokyo (5-5 rule)[53] | LDLT | Maximum 5 tumors ≤ 5 cm |
| Kyoto[55] | LDLT | ≤ 10 tumors, ≤ 5 cm, DCP§ ≤ 400 mAU/mL |
| Kyushu University[57] | LDLT | Any number of tumors with diameter ≤ 5 cm or DCP§ ≤ 300 mAU/mL |
| Asan[58] | LDLT | ≤ 6 tumors, diameter ≤ 5 cm |
| Samsung[59] | LDLT/cadaveric | ≤ 7 tumors, diameter ≤ 6 cm, AFP ≤ 1000 ng/mL |
| BCLC[14] | LDLT | 1 tumor, ≤ 7 cm 3 tumors, ≤ 5 cm 5 tumors, ≤ 3 cm Maintained response within Milan criteria during 6 mo after downstaging |
AFP: Alpha-fetoprotein; BCLC: Barcelona-Clínic Liver Cancer; DCP: Des-gamma-carboxy prothrombin; LDLT: Living donor liver transplantation; LT: Liver transplantation.