Table 2.
Locus | Candidate gene | SNP | Distance to gene (kb) | EA | EAF | Discovery stage* |
|
Replication stage* |
|
Combined* | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Odds ratio (95% CI) | P | Odds ratio (95% CI) | P | Odds ratio (95% CI) | P | No of fracture cases |
I2 | ||||||||
2p16.2 | SPTBN1 | rs4233949 | −23.21 | G | 0.61 | 1.03 (1.02 to 1.05) | 6.9×10−5 | 1.04 (1.05 to 1.05) | 8.9×10−11 | 1.03 (1.02 to 1.04) | 2.8×10−14 | 185 057 | 22.4 | ||
3p22.1 | CTNNB1 | rs430727 | 107.2 | T | 0.45 | 1.03 (1.02 to 1.05) | 1.0×10−4 | 1.03 (1.02 to 1.04) | 1.1×10−8 | 1.03 (1.02 to 1.04) | 5.0×10−12 | 185 057 | 0 | ||
6q22.33 | RSPO3 | rs10457487 | 0 | C | 0.51 | 1.06 (1.05 to 1.08) | 2.3×10−15 | 1.04 (1.03 to 1.05) | 1.7×10−15 | 1.05 (1.04 to 1.06) | 4.8×10−28 | 185 057 | 5 | ||
6q25.1 | ESR1 | rs2982570 | 0 | C | 0.58 | 1.05 (1.04 to 1.07) | 8.1×10−12 | 1.03 (1.02 to 1.04) | 5.2×10−10 | 1.04 (1.03 to 1.05) | 4.5×10−19 | 185 057 | 23 | ||
7q31.31 | WNT16, CPED1 | rs2908007 | −3.25, 24.67 | A | 0.60 | 1.08 (1.06 to 1.10) | 1.2×10−20 | 1.05 (1.04 to 1.06) | 5.6×10−22 | 1.06 (1.05 to 1.07) | 2.3×10−39 | 185 055 | 0 | ||
7q21.3 | C7orf76, SHFM1 | rs6465508 | 0, 0 | G | 0.34 | 1.05 (1.03 to 1.07) | 4.0×10−9 | 1.04 (1.03 to 1.05) | 4.1×10−12 | 1.04 (1.03 to 1.05) | 2.0×10−19 | 185 056 | 35 | ||
7p14.1 | STARD3NL | rs6959212 | −89.01 | T | 0.34 | 1.04 (1.02 to 1.06) | 6.9×10−6 | 1.02 (1.01 to 1.04) | 1.1×10−5 | 1.03 (1.02 to 1.04) | 8.8×10−10 | 185 057 | 15.6 | ||
7p12.1 | GRB10, COBL | rs1548607 | 40.33, −182.4 | G | 0.32 | 1.05 (1.03 to 1.07) | 3.2×10−8 | 1.02 (1.01 to 1.04) | 2.1×10−4 | 1.03 (1.02 to 1.05) | 4.7×10−10 | 185 052 | 40 | ||
9q34.11 | FUBP3 | rs7851693 | 0 | G | 0.35 | 1.03 (1.01 to 1.06) | 1.3×10−4 | 1.05 (1.06 to 1.06) | 4.8×10−16 | 1.04 (1.03 to 1.05) | 5.0×10−19 | 185 057 | 23.5 | ||
10q21.1 | MBL2/DKK1 | rs11003047 | −90.63 | G | 0.11 | 1.09 (1.07 to 1.12) | 6.2×10−12 | 1.08 (1.07 to 1.10) | 1.4×10−21 | 1.09 (1.07 to 1.10) | 9.5×10−33 | 185 057 | 0 | ||
11q13.2 | LRP5 | rs3736228 | 0 | T | 0.15 | 1.05 (1.03 to 1.07) | 3.0×10−5 | 1.07 (1.05 to 1.08) | 2.8×10−18 | 1.06 (1.05 to 1.08) | 1.0×10−21 | 185 056 | 24.6 | ||
14q32.12 | RPS6KA5 | rs1286083 | 0 | T | 0.82 | 1.04 (1.02 to 1.06) | 8.8×10−5 | 1.05 (1.04 to 1.07) | 3.0×10−14 | 1.05 (1.04 to 1.06) | 1.6×10−17 | 185 085 | 43.3 | ||
17q21.31 | SOST, DUSP3, MEOX1 | rs2741856 | −4.26, −16.65, 88.02 | G | 0.92 | 1.11 (1.08 to 1.14) | 2.4×10−12 | 1.08 (1.06 to 1.11) | 5.3×10−15 | 1.10 (1.07 to 1.11) | 3.1×10−25 | 184 977 | 0 | ||
18p11.21 | FAM210A, RNMT | rs4635400 | 0, −7.149 | A | 0.36 | 1.06 (1.04 to 1.07) | 1.5×10−12 | 1.03 (1.02 to 1.04) | 2.7×10−9 | 1.04 (1.03 to 1.05) | 1.1×10−18 | 185 057 | 22 | ||
21q22.2 | ETS2 | rs9980072 | 141.9 | G | 0.73 | 1.06 (1.04 to 1.08) | 8.4×10−12 | 1.03 (1.01 to 1.04) | 1.8×10−5 | 1.04 (1.03 to 1.05) | 3.4×10−13 | 185 057 | 36 |
EA=effect allele; EAF=effect allele frequency; I2=index of heterogeneity.
Discovery stage (37 857 cases; 227 116 controls); replication stage (147 200 cases; 150 085 controls); combined (185 057 cases; 377 201 controls).