Table 3.
Estimated genetic correlation between fracture and other clinical risk factors
| Disease or trait | Genetic correlation (95%CI) | P | |
|---|---|---|---|
| Femoral neck bone mineral density | −0.59 (−0.70 to −0.48) | 2×10−24 | |
| Lumbar spine bone mineral density | −0.53 (−0.64 to −0.42) | 1×10−20 | |
| Age at menopause | −0.12 (−0.23 to −0.003) | 0.04 | |
| Rheumatoid arthritis | 0.02 (−0.10 to 0.14) | 0.74 | |
| Inflammatory bowel disease | −0.01 (−0.13 to 0.11) | 0.90 | |
| Homocysteine levels | 0.22 (0.07 to 0.37) | 0.004 | |
| Grip strength | −0.10 (−0.21 to 0.01) | 0.07 | |
| Age of puberty | 0.03 (−0.05 to 0.11) | 0.43 | |
| Fasting glucose | −0.05 (−0.19 to 0.09) | 0.46 | |
| Coronary heart disease | −0.05 (−0.09 to 0.19) | 0.48 | |
| Type 2 diabetes | −0.07 (−0.22 to 0.08) | 0.35 | |
| Vitamin D levels | 0.23 (−0.52 to 0.98) | 0.56 | |