Figure 1.

Schematic representation of the challenges and perspectives of continuing along the road of translational research. Critical milestones include testing our approach in human cells, including patient-derived tumor and immune cells, and models of spontaneous tumors, such as canine melanoma. In addition, the combination of our approach with chemotherapy or other immunotherapies may enhance efficacy. Virus production following good manufacturing practices (GMP) is critical for providing not only larger quantities of vectors but also biological agents of pharmaceutical quality.