Table 2. FQ-resistance markers in NTS, reported by WGS.
Reference | Region or country | n | NTS serovar | Source | % FQR markers | FQ-resistance marker | ||||
---|---|---|---|---|---|---|---|---|---|---|
PMQR | Mutations in gyr and par | |||||||||
gyrA | gyrB | parC | parE | |||||||
[67] | Scotland | 290 | Typhimurium DT104 | H, A | 13 | – | Ser83Phe | – | – | – |
– | Asp87G | – | – | – | ||||||
– | Asp87Asn | – | – | – | ||||||
[10] | Africa, Asia, Europe, Americas | 675 | Enteritidis | H, A | 0.15 | – | – | – | – | – |
Africa | 496 | qnrS | – | – | – | – | ||||
[69] | USA | 640 | 12 NTS serotypes | H | 3 | – | Asp87Tyr | – | – | – |
– | Ser83Phe | – | – | – | ||||||
– | Asp87Tyr+Ser83Phe | – | Ser80Ile | – | ||||||
qnrS | – | – | – | – | ||||||
qnrB | – | – | – | – | ||||||
qnrB+oqxA+oqXB | – | – | – | – | ||||||
[68] | USA (New York and Washington) | 90 | Typhimurium | H | 7 | qnrS | – | – | – | – |
oqxA, oqxB | Asp87Tyr | – | – | – | ||||||
oqxA, oqxB | Ser83Tyr | – | – | – | ||||||
qnrB | – | – | – | – | ||||||
oqxA, oqxB | Asp87Asn | – | – | – | ||||||
– | Asp87Asn | – | – | – | ||||||
[66] | USA, Europe | 659 | 4,[4],12:i:- | A | 5 | qnrB, qnrS | – | – | – | – |
[64] | Morocco, unknown | 153 | Chester | H | 54 | qnrS, qnrB | – | – | – | – |
[81] | South Asia, South-East Asia and Oceania | 115 | Weltevreden | H, A | na | qnrD, qnrS | – | – | – | – |
oqxA, oqxB | – | – | – | – | ||||||
[80] | Southern China | 44 | Weltevreden | H | 5 | qnrD | – | – | – | – |
qnrS | – | – | – | – | ||||||
[65] | Chile | 30 | Enteritidis | A | 7 | qnrB | – | – | – | – |
2018* | Vietnam | na | Typhimurium | H | na | qnrS | Asp87Asn | – | – | – |
*S. Baker, personal communication (2018).