Figure 2.

Influence of SERCA on hub importance. (A) ${\left[C{a}^{2+}\right]}_i$ activity in a mouse islet model as a function of the number of cells inhibited (% of islet). Either hubs or non-hubs were inhibited, and ${\left[C{a}^{2+}\right]}_i$ activity (% of no inhibition) was quantified. The value of $P_{SERCA}$ (the maximum flux of Ca²⁺ through the SERCA pump) in this model was set to its default value (0.096 amole/ms), according to the Cha-Noma model. (B) Same as in (A) but where $P_{SERCA}$ was reduced by 40%. (C) Same as in (B) but displaying hub inhibition only, with graded reduction in $P_{SERCA}$.