FIGURE 5.

Increased ROS production by high salt contributed to endothelial dysfunction. MAECs were cultured in normal, or high salt (HS), or HS + Catalase (a H₂O₂ catalyzing enzyme) medium. (A,B) HS induced a higher level of ROS production in MAECs, n = 4 for each group. (C,D) Catalase significantly improved the impaired angiogenic function by HS, n = 5 for each group. Values are shown as means ± SEM. ^∗∗P < 0.01 vs. Control, ^##P < 0.01 vs. HS. (B, Unpaired t-test was used; D, one-way ANOVA was used).