Table 1. Hepatoprotective activities of STAT3 identified in mouse models and published during the last 5 years.

STAT3-protective function	Involved liver cell types	STAT3-activating cytokine(s)	Involved genes	Ref.
Alcoholic liver injury	Hepatocytes	IL-22	FATP, MTI/II and LCN2	[71]
Alcoholic liver injury	Endothelial cells	IL-6	ND	[81]
Alcoholic liver injury	Kupffer cells, hepatocytes	IL-6	FASN, SREBP-1, ACC1, SCD1, CPT1 and PPAR-α	[84]
Alcoholic and nonalcoholic steatohepatitis	Hepatocytes	IL-6, IL-10	FASN, SREBP-1 and ACC1	[74]
CCL4-induced liver inflammation	Kupffer cells, hepatocytes	IL-6, OSM, IL-10	TNF-α, IFN-γ, Mip1α, MCP1, IL-1β, ICAM1, VCAM1, MIP2 and C5	[83]
CCL4-induced liver fibrosis	Stellate cells	IL-22	p53, p21 and SOCS3	[100]
Cholestatic liver injury	Hepatocytes, cholangiocytes	IL-6	EGFR, IGF-1 and bile acid biosynthesis genes	[77]
Cholestatic liver injury	Hepatocytes, cholangiocytes	IL-6	Acute phase response genes	[78]
Cholestatic and hepatotoxic liver injury and fibrosis	Kupffer cells, stellate cells	IL-17, IL-22	TGF-β1, IL-6, TNF-α, IL-1β, α-SMA, Col1-α1(I), MMP3 and TIMP1	[73]
ConA-induced T-cell mediated hepatitis	Kupffer cells	IL-22	IFN-γ and IL-17	[85]
D-Galactosamine/LPS-induced acute liver failure	Hepatocytes	IL-22	bcl-XL, HO-1 and Ref-1	[75]
Steatohepatitis	Hepatocytes	IL-6	SAA, SOCS3, FASN, SREBP-1, TNF-α and ADIPOQ	[72]
Steatosis	Hepatocytes	IL-22	SREBP-1, PPAR-γ, PPAR-α, LXR-α, LXR-β, ChREBP, FASN, SCD1, ACC1, ACLY, GPAM, DGAT2, ELOVL6 and HMGCR	[76]

For a comprehensive overview regarding hepatoprotective STAT3 functions reported before 2008 see [52].

ConA: ConcanavalinA; LPS: Lipopolysaccharide; ND: Not defined.