Table 4.

Most genes with FDSIs have biochemically distinct splice isoforms

	Types of distinctness	Human genes	Mouse genes
Distinct expression patterns	Cell-type-specific	AR, MADD
	Developmental-stage-specific	CD44	Myh10, Robo3
	Cellular localization	BIRC5, CSPP1, PRMT5, PML	Myh10, Rbfox1, Robo3, Sirt3
	Tissue-specific	MST1R	Calca, Rock2
	Other-condition-specific	BOK
Biochemically distinct	Protein domain	CFLAR, DPF3, EIF4G1, TICAM1, TP63	Lrp8
	Dominant negative	BIRC5, HBS1L, KLF6, Nf1, PRMT5, STIM2, SUN1, TICAM	Enc1, Nf1, Robo3, Ryr3, Tp63
	Protein terminus change	BCAR1, BDNF, EIF4G2, IL1RAP, PGAM5	Cacna1b, Mecp2, Oprm1, Pn4
	UTR Change	BDNF

Genes with FDSIs were categorized on functional type based on the literature that reported on the FDSIs using the scheme outlined in Fig. 1. Genes categorized as “distinct expression patterns” express FDSIs in specific conditions. Genes categorized as “biochemically distinct” have FDSIs whose functional distinctness is a consequence of biochemical differences in their final protein product. Genes can be categorized as both “distinct expression patterns” and “biochemically distinct” such as Myh10 and Robo3