Table 1.
Group | Number of pregnant ewes | Number of foetuses/lambs | Inoculum (i.v.) | Treatment (s.c.) |
---|---|---|---|---|
G1 | 8 | 14 | Nc-Spain7 106 tachyzoites |
BKI-1553, 1st dose: 35 mg/kg bodyweight; a week later, a 2nd dose at 10 mg/kg bodyweight |
G2 | 5 | 7 | PBS | BKI-1553, 1st dose: 35 mg/kg bodyweight; a week later, a 2nd dose at 10 mg/kg bodyweight |
G3 | 8 | 13 | Nc-Spain7 106 tachyzoites |
BKI-1553, 7 doses at 10 mg/kg bodyweight every other day |
G4 | 5 | 9 | PBS | BKI-1553, 7 doses at 10 mg/kg bodyweight every other day |
G5 | 8 | 13 | Nc-Spain7 106 tachyzoites |
None |
G6 | 3 | 5 | PBS | None |
i.v.: intravenous route.
s.c.: subcutaneous route.