Table 2.

Haematological and biochemical parameters at initial and final time points.

Parameter (units)	Reference values	G1		G2		G3		G4		G5		G6
		Initial	Final	Initial	Final	Initial	Final	Initial	Final	Initial	Final	Initial	Final
Erythrocytes (x106/mL)	9–14	10.99 ± 0.78	9.35 ± 1.09	10.70 ± 1.12	8.57 ± 0.83	10.49 ± 1.16	8.46 ± 1.40	10.62 ± 1.04	9.54 ± 0.59	9.76 ± 0.55	8.94 ± 0.74	10.81 ± 0.93	9.46 ± 0.44
Haemoglobin (g/dL)	8–15	12.31 ± 0.59	10.35 ± 1.22	12.10 ± 1.21	9.72 ± 1.13	11.75 ± 1.07	9.58 ± 1.31	11.56 ± 1.09	10.70 ± 0.59	10.79 ± 0.58	10.3 ± 0.76	11.83 ± 1.20	10.96 ± 0.90
Packed cell volume (%)	28–40	35.07 ± 2	30.48 ± 3.46	33.58 ± 3.31	27.66 ± 2.94	32.29 ± 2.54	26.73 ± 3.73	33.24 ± 2.56	30.52 ± 1.07	31.70 ± 2.39	29.63 ± 3.11	33.73 ± 3.37	30.33 ± 1.62
Platelets (x103/mL)	250–750	498.50 ± 172.18	565.62 ± 186.80	442.20 ± 125.70	551.60 ± 207.95	476.50 ± 133.77	674.12 ± 255.49	402 ± 92.32	562.80 ± 146.51	470 ± 131.31	584 ± 150.43	440.33 ± 83.97	447.66 ± 48.08
Leukocytes (x103/mL)	4–12	6.50 ± 0.83	5.33 ± 1.97	7.90 ± 1.76	6.98 ± 1.24	6.55 ± 1.12	6.90 ± 2.15	6.96 ± 1.49	6.91 ± 1.16	7.58 ± 1.98	5.69 ± 1.29	7.38 ± 3.28	7.03 ± 2.39
Segment neutrophils (%)	10–50	29.73 ± 4.46	35.63 ± 12.08	25.72 ± 7.81	32.32 ± 7.86	31.13 ± 7.64	36.27 ± 10.68	27.10 ± 7.03	33.24 ± 2.93	31.11 ± 7.71	24.12 ± 3.96	24.90 ± 8.57	29.86 ± 6.52
Lymphocytes (%)	40–75	60.01 ± 5.82	56.67 ± 10.69	63.16 ± 13.24	58.20 ± 9.84	59.31 ± 8.19	50.56 ± 8.77	63.48 ± 6.88	57.86 ± 3.51	58.94 ± 9.37	66.48 ± 4.85**	65.53 ± 9.43	59.40 ± 9.24
Monocytes (%)	1–6	3.66 ± 1.25	2.78 ± 2.63	4.26 ± 1.75	3.80 ± 0.90	5.20 ± 2.44	6.91 ± 3.96*	4.24 ± 1.56	3.78 ± 0.17	3.78 ± 1.80	5.20 ± 2.20	3.40 ± 0.60	3.90 ± 1.38
Eosinophils (%)	0–15	5.37 ± 2.50	3.13 ± 1.05	5.62 ± 6.80	4.84 ± 2.06	3.04 ± 1.13	3.71 ± 2.35	3.86 ± 1.45	3.08 ± 1.25	4.94 ± 2.99	2.13 ± 0.48	4.90 ± 0.95	5.30 ± 3.17
Proteins (g/dL)	6–8	6.83 ± 0.63	6.08 ± 0.35	7.10 ± 0.86	6.18 ± 0.30	6.94 ± 0.71	6.52 ± 0.32	6.52 ± 0.33	6.32 ± 0.31	7.33 ± 0.91	6.31 ± 0.19	6.23 ± 0.45	6.46 ± 0.35
AST (UI/L)	70–210	72.75 ± 9.57	128.50 ± 15.40	131.40 ± 41.29	114.8 ± 26.78	76.88 ± 15.26	121 ± 46.03	79.60 ± 6.80	65.20 ± 4.76	92.13 ± 18.21	192.75 ± 49.41**	75.33 ± 10.59	68.66 ± 6.11
GGT (UI/L)	36–93	67.50 ± 7.17	57.12 ± 7.98	83.80 ± 14.78	65.80 ± 11.43	73.13 ± 6.55	71.50 ± 10.05	64.40 ± 2.30	67.20 ± 7.91	62.38 ± 26.25	70.12 ± 15.19	56.33 ± 10.59	57.33 ± 7.57
ALP (UI/L)	44–355	370.37 ± 105.27	387.75 ± 257.94	482 ± 92.32*	680.20 ± 119.35**	326.88 ± 59.68	358.50 ± 130.59	457 ± 231.50	423 ± 212.15	364 ± 91.51	247.75 ± 61.93	448 ± 142.67	553.66 ± 244.96
CK (UI/L)	50–180	374.12 ± 108.24	251.62 ± 83.79	386 ± 60.02	226.60 ± 75.84	384.25 ± 83.03	314.12 ± 142.03	423 ± 147.85	321.8 ± 96.69	376.38 ± 79.22	396.75 ± 194.55	363.67 ± 158.79	313.33 ± 198.04
Urea (mg/dL)	8.4–30.8	15.60 ± 2.82	8.96 ± 2.31*	15.54 ± 0.71	10.20 ± 1.86	14.59 ± 4.15	13.73 ± 3.13	15.94 ± 3.71	12.48 ± 2.46	15.89 ± 2.73	13.18 ± 3.83	12.73 ± 4.85	12.60 ± 1.12
Creatinine (mg/dL)	0.9–1.7	0.96 ± 0.09	0.75 ± 0.10	1.02 ± 0.13	0.86 ± 0.05	0.94 ± 0.11	0.77 ± 0.07	0.90 ± 0.07	0.78 ± 0.04	0.93 ± 0.10	0.86 ± 0.10	0.83 ± 0.11	0.86 ± 0.05
Calcium (mg/dL)	7.1–9.8	9.92 ± 0.77	9.91 ± 0.62	9.86 ± 0.87	9.88 ± 0.43	9.61 ± 0.70	9.73 ± 0.48	9.82 ± 0.38	10.14 ± 0.39	8.94 ± 3.32	10.75 ± 0.37*	9.87 ± 0.25	10.63 ± 0.25
Phosphorus (mg/dL)	3.5–7.3	7.11 ± 1.03	6.50 ± 0.75	6.62 ± 1.66	6.06 ± 0.87	6.59 ± 1.05	6.17 ± 0.56	6.02 ± 0.27	5.76 ± 0.75	6.35 ± 0.82	6.12 ± 1.01	5.63 ± 0.61	5.30 ± 0.26
Sodium (mEq/L)	139–152	150.37 ± 6.18	143.5 ± 1.60	149.80 ± 6.72	143 ± 3.08	148.25 ± 3.10	145.25 ± 1.90	152.20 ± 13.33	145.60 ± 0.54	158.88 ± 13.27	144.87 ± 1.35	148 ± 1.73	145 ± 0
Potassium (mEq/L)	3.9–5.2	5.21 ± 0.22	4.91 ± 0.15	5.12 ± 0.32	4.88 ± 0.29	5.15 ± 0.34	4.92 ± 0.33	5.12 ± 0.21	5.14 ± 0.21	4.94 ± 0.39	4.80 ± 0.26	4.67 ± 0.05	4.80 ± 0.10

Values are represented as Means ± S.D. (*), P < 0.05 and (**), P < 0.01, indicating significant differences between groups at each time point for each parameter.