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. 2018 Jan 31;8(1):70–80. doi: 10.1016/j.ijpddr.2018.01.004

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 1 — Amino Acid Sequence of Tci-pgp-9

Amino acid sequences from the UK isolates MTci2 and MTci5, aligned with sequence information derived from two near-isogenic strains of T. circumcincta from NZ. The first of the NZ strains (NZ-S) was known to be susceptible to all available anthelmintics while the second (NZ-R), which shared a largely common genetic background, was multiple-anthelmintic resistant. Sequence motifs are underlined and annotated above the sequence. The positions of inter-nucleotide binding domains A and B (IBDA and IBDB) are underlined and annotated below the sequences. Highlighted in yellow are six residue substitutions identified in the UK isolates (numbered 1–6), and four previously identified residue substitutions in NZ isogenic strains (annotated A-D).

Fig. 1 — Amino Acid Sequence of Tci-pgp-9

Amino acid sequences from the UK isolates MTci2 and MTci5, aligned with sequence information derived from two near-isogenic strains of T. circumcincta from NZ. The first of the NZ strains (NZ-S) was known to be susceptible to all available anthelmintics while the second (NZ-R), which shared a largely common genetic background, was multiple-anthelmintic resistant. Sequence motifs are underlined and annotated above the sequence. The positions of inter-nucleotide binding domains A and B (IBDA and IBDB) are underlined and annotated below the sequences. Highlighted in yellow are six residue substitutions identified in the UK isolates (numbered 1–6), and four previously identified residue substitutions in NZ isogenic strains (annotated A-D).