Table 3.

List of main peaks for ABZ biotransformation samples detected by UHPLC-MS/MS with their retention times, theoretical values of [M+H]⁺ ions in ESI positive-ion mode, elemental composition, product ions, and description of present metabolites.

tR [min]	Theoretical m/z values of [M+H]+ ions	Elemental composition	Description of metabolite formation		Product ions of [M+H]+, m/z	Metabolite designation
			Phase I	Phase II
1.83	444.14	C18H25N3O8S	S-oxidation	N-glycosidation	282, 240, 208, 191, 159	M1ABZ
2.33	444.14	C18H25N3O8S	S-oxidation	N-glycosidation	282, 240, 208	M2ABZ
3.32	282.09	C12H15N3O3S	S-oxidation	–	240, 208, 191,159	M3ABZ
3.56	370.14	C16H23N3O5S	Hydrolysis	N-glycosidation	208	M4ABZ
4.53	370.14	C16H23N3O5S	Hydrolysis	N-glycosidation	208	M5ABZ
5.22	298.09	C12H15N3O4S	2*S-oxidation	–	266, 224, 159	M6ABZ
5.65	428.15	C18H25N3O7S	–	N-glycosidation	266, 234, 191	M7ABZ
6.16	428.15	C18H25N3O7S	–	N-glycosidation	266, 234	M8ABZ
6.71	428.15	C18H25N3O7S	–	N-glycosidation	266, 234	M9ABZ
7.5	266.10	C12H15N3O2S	–	–	234	ABZ (parent drug)