Table 7.
Relative amount of unchanged parent drugs in homogenate of H. contortus adults.
| Relative amount of unmetabolized parent drugs [%] |
||||
|---|---|---|---|---|
| ISE |
IRE |
|||
| Female | Male | Female | Male | |
| Flubendazole | 79.5 ± 6.4 | 90.3 ± 1.0 | 58.5 ± 3.8a | 90.8 ± 8.0 |
| Albendazole | 64.2 ± 2.4 | 81.2 ± 9.3 | 27.5 ± 3.9a | 72.6 ± 8.5 |
| Ricobendazole | 89.3 ± 11.5 | 82.1 ± 17.5 | 87.4 ± 12.6 | 90.7 ± 6.2 |
The sum of normalized peak areas of parent drug and all metabolites in each sample represent 100%. The data represent the mean ± S.D. from 3 parallels (n = 3).
a
Significant difference between females of the ISE and IRE strains, P < 0.05.