Table 4.

In vitro susceptibility profile of the selected L. infantum strains against the various DNDi lead compounds. Results are expressed as the mean IC₅₀ (μM) ± standard error of mean (SEM) and are based on three independent experiments with biological duplicates (n = 6).

MEAN IC50	NITROIMIDAZOLES			AMINOPYRAZOLES		OXABOROLES
	DNDI-0690	DNDI-8219	DNDI-VL-2098	DNDI-1044	DNDI-8012	DNDI-6148	DNDI-5421
L. infantum	MEAN ± SEM	MEAN ± SEM	MEAN ± SEM	MEAN ± SEM	MEAN ± SEM	MEAN ± SEM	MEAN ± SEM
ITMAP263	0.33 ± 0.10	0.90 ± 0.50	0.40 ± 0.00	0.10 ± 0.04	0.09 ± 0.03	1.05 ± 0.29	1.03 ± 0.26
L3034	0.05 ± 0.04	0.80 ± 0.00	0.90 ± 0.40	0.02 ± 0.01	0.04 ± 0.01	0.27 ± 0.11	0.89 ± 0.25
LEM5695	0.01 ± 0.00	0.17 ± 0.08	0.21 ± 0.10	0.08 ± 0.08	0.01 ± 0.01	0.04 ± 0.03	0.02 ± 0.01
LEM5159	0.17 ± 0.07	2.10 ± 0.50	1.70 ± 0.70	0.07 ± 0.03	0.09 ± 0.03	0.38 ± 0.22	0.52 ± 0.31
LEM3323CL4	0.10 ± 0.07	2.20 ± 1.00	1.30 ± 0.20	0.14 ± 0.05	0.31 ± 0.15	0.27 ± 0.11	0.89 ± 0.25
LEM3323CL4 PMM	0.09 ± 0.02	2.10 ± 0.90	0.80 ± 0.50	0.30 ± 0.10	0.83 ± 0.22	0.69 ± 0.51	1.08 ± 0.31
LEM3323CL4 MIL	0.01 ± 0.01	0.80 ± 0.20	1.10 ± 0.00	0.04 ± 0.02	0.09 ± 0.05	0.03 ± 0.01	0.02 ± 0.01