(A-B) Representative particle size and size distribution profiles of Alhydrogel® (A) and Imject™ Alum (B), respectively, as determined by laser diffraction. (C) Uric acid induction by Alhydrogel®. BALB/c mice were i.p. injected with OVA- adsorbed Alhydrogel (Aluminum, 263 μg/mouse; OVA 10 μg/mouse) or normal saline. Uric acid level was determined in the peritoneal lavage after 6 h. Data shown are mean ± SEM (n = 5). * p < 0.0005 vs. normal saline. (D) An overlay of the particle size distribution curves of AH-NPs, AH-MPs, Imject™ Alum, and Alhydrogel®.