Table 3:

Stability data of abiraterone

Nominal conc. (ng/mL)	Determined mean (ng/mL) (n=3)	Mean accuracy % (n=3)
Stock solution 1 mg/mL (− 40°C, 7 months)	1.03	103
Quality control stability (− 40°C, 6 months)
5.00	4.7	93.2
300	308.3	103.0
400	410.0	102.7
Plasma 3 freeze-thaw (F/T) cycles
5.00	5.0	100.4
300	299.1	99.7
400	395.9	98.9
Plasma, (2-8°C), 8 days
5.00	5.4	107.0
300	298.4	99.5
400	388.0	97.0
Plasma, ambient temp, 8 days
5.00	5.2	103.5
300	298.5	99.5
400	396.2	99.1
Extract, autosampler (2-8°C), 8 days
5.00	5.1	102.5
300	299.0	99.7
400	405.8	101.5
Patient samples short term stability (2-8ºC) (% of baseline measurement)
Plasma 24hr Whole blood 24hr	95.5 99.0
Patient samples short term stability (ambient temperature) (% of baseline measurement)
Whole blood 2hr Whole blood 4 hr Plasma 2hr Plasma 3hr Plasma 4hr	83.0 76.0 86.0 81.5 75.0