Fig. 8.

a, b Line graphs showing the effect of gonadectomy on glucose tolerance in male and female Mito-Ob mice as determined by glucose tolerance test. Sham operated mice are included as control. Data are presented as mean ± SEM (n = 8). *p < 0.05 represent significant differences between orchiectomized Mito-Ob mice or wild-type mice vs. respective sham-operated male mice. No significant difference was found in female mice. c, d Line graphs showing the effect of gonadectomy on insulin sensitivity in male and female Mito-Ob mice as determined by insulin tolerance test. Sham-operated mice are included as control. Data are presented as Mean ± SEM (n = 8). *p < 0.05 and **p < 0.01 represent significant differences between gonadectomized wild-type mice vs. sham-operated wild-type mice. No significant difference was found between gonadectomized Mito-Ob mice vs. sham-operated Mito-Ob mice. Ovx—ovariectomy; Orchx—orchiectomy; Wt—wild-type