Table 1.
Clinical Characteristics of 5 Cases of HIV-Associated Cryptococcal Meningitis and Tuberculous Meningitis Co-infection
| Case | Age | Sex | Days on ART | CD4 Cells/μL | History of CM | History of TB | Days From CM to TBM Diagnosis | CSF TB Diagnostics | CSF White Cells/μL | CSF Protein, mg/dL | C ryptococcus CFU/ mL CSF | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 40 | F | 30 | 10 | 12 y prior | Y | 11 | Xpert MTB/RIF (-) MGIT culture (+) |
<5 155a |
20 74a |
0 0a |
Death, day 10 |
| 2 | 35 | M | 13 186b |
79 | N | N | 173 | Xpert Ultra (+) MGIT culture not done |
115 2200b |
157 356b |
12 300 0b |
Alive at discharge |
| 3 | 26 | M | 35 | 19 | N | N | 0 | Xpert Ultra (+) MGIT culture (-) |
205 | 100 | 0 | Death, day 11 |
| 4 | 32 | M | 11 | 1 | N | Y | 0 | Xpert Ultra (+) MGIT culture contaminated |
210 | 40 | 520 000 | Death, day 2 |
| 5 | 32 | M | 5 | 3 | N | N | 0 | Xpert Ultra (+) MGIT culture not done |
<5 | N/A | 20 000 | Alive >18 wk |
Abbreviations: ART, antiretroviral therapy; CFU, colony-forming units; CM, cryptococcal meningitis; CSF, cerebrospinal fluid; MGIT, mycobacteria growth indicator tube; TB, tuberculosis; TBM, tuberculous meningitis.
aDay 3 lumbar puncture.
bAt the time of TBM diagnosis.